Composition And Presentation
Each tablets contains... Diphenoxylate hydrochloride 2.5 mg, Atropine Sulphate 25 mg.
Indications:
Therapy to provide symptomatic relief which may be adjunctive to appropriate rehydration in diarrhoea. Control of stool formation after colostomy or ileostomy, relief of symptoms in chronic mild ulcerative colitis.
Contradictions:
Detropine is contraindicated in patient with known hypersensivity to diphenoxylate or atropine, and in patients with jaundice. Detropine is also contradicated in patients with diarrhoea associated with pseudomembranous enterocolitisor entrotoxin- producing bacteria.
Warnings:
Detropine is not an innocuous drug and dosage recommendations should be strictly adhered to especially in children. Detropine is not recommended for children under 4 years of age overdosages may result in severe respiratory or depression and coma, possibly leading to permanent brain damage . Therefore keep ths medication out of reach of children.
Detropine should be used with extreme caution in patients with advanced hepatorenal disease and in all patients with abnormal liver fuction. Since hepatic coma may be precipitated. Bacterially induced diarrhoea should be treated with appropriate antimicrobial therapy.
Precautions:
A subtherapeutic dose of atropine has been added to detropine consideration should be given to the precautions relating to the use of atropine in children. Detropine should be used with caution since signs of atropine may occur particularly in patients Down's Syndrome.
Keep out of reach of children.
Indications:
Therapy to provide symptomatic relief which may be adjunctive to appropriate rehydration in diarrhoea. Control of stool formation after colostomy or ileostomy, relief of symptoms in chronic mild ulcerative colitis.
Contradictions:
Detropine is contraindicated in patient with known hypersensivity to diphenoxylate or atropine, and in patients with jaundice. Detropine is also contradicated in patients with diarrhoea associated with pseudomembranous enterocolitisor entrotoxin- producing bacteria.
Warnings:
Detropine is not an innocuous drug and dosage recommendations should be strictly adhered to especially in children. Detropine is not recommended for children under 4 years of age overdosages may result in severe respiratory or depression and coma, possibly leading to permanent brain damage . Therefore keep ths medication out of reach of children.
Detropine should be used with extreme caution in patients with advanced hepatorenal disease and in all patients with abnormal liver fuction. Since hepatic coma may be precipitated. Bacterially induced diarrhoea should be treated with appropriate antimicrobial therapy.
Precautions:
A subtherapeutic dose of atropine has been added to detropine consideration should be given to the precautions relating to the use of atropine in children. Detropine should be used with caution since signs of atropine may occur particularly in patients Down's Syndrome.
Keep out of reach of children.
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