Propertles:
Antiallergic agent; Allergic reaction inhibitor. In experimental animais,cetirzine exhibits an anti-h1 activity without any significant anticholin. Ergic and antiserotonin effects. At pharmacologically active doses, cetirizine induces neither sedation nor dehavioral modifications. Cetirizine nor behavioral modifications. Cetirizine exhibits a powerful and iasting anfagonisic effect particularly selective at the level of the H1- receptors. In human pharmacology, its periheral activity is demonstrated by the clearly sihnificant inhibition of:
1-the immediate wheal and flare reaction induced by intracutaneous injection of histamine.
2- the endogenous histamine released in viva as a result of stimulation by 48/80
3- the immediate allergic skin reaction triggered by an intracutaneous injection of pollen.
4- the oedmatous sikn reaction induced by substance p or VIP(vasoactive intestinal polypeptide).
5- the immediate allergic nasal reaction triggred by instillation of an allergen.
These effect are achieved without any central effect being objectively demonstrated neither by psychometric tests nor by duantifieb EEG. A 10 mg intake of cetirizine produces a blood peak of about 0.3/uh/ml between the30 Th and 60 Th minutes. Lts plasma half- life- time is approximare-ly 11hours. It should be noted that resorption is very regular in every subject. Its renal clerance is 30mi/min and the half- excretion time is about 9 hours.
Pregnancy and lactation:
Teratological studies carried out in animals did not evidence any particular malformation. However, as a precaution cetirizine should not be administered to pregnant women during the perod of organ
ogenesis. The same applies to lactation period.
Interactions:
No interaction has been reported so far.
Storage:
Store at room temperature.
Protect from light freezing and excessive heat.
Stability:
Check whether the expiry date on the packaging after the word, Exp, has nos not passed.
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