Presentation and composition

Tabets:Yellow scorew unccated stamped”Searle on one side each containing dimenhydrinate B. P. 50 mg .

Loquid:Cherry flavoured each 4ml containing Dimenhydrinate B.P.12.mg.

Ampoules:1 ml ampoules each containing Dimenhydrinate B.P. 50mg.

Lndlations:Prevention and relief and motion sickness and treatment of vertigo nausea or vomiting associated with: electroshock therapy anaesthesia and surgery labyrinthine disturbances radiation sickess and postfenestration syndrome.DosGE Oral children 4ml of Gravinate liquid contains 12.5mg of Dimenhydrinate. The liquid dosage form is recommended for children. For children 5mg/kg daily in 2 or 3 divided doses is recommended.Children: 2-6 years 12.5-25 mg (4-8 ml ) 2to 3 times daily 6-12 years 25-50 mg (8-16ml) 2to3timmes daily or use as directed by the physician.

Contralndlcatlons:Hypersensitivity to the active ingredient epilepsy infants and children under 5 years of age to increased susceptibility to anticholinergic agents and their effects (CNS  excitation and increased tendency toward convulsions) narrowangle glaucoma prostatic hypertrophy urinary retention severe hepatic function impairmebt.

Precautions and warnings:Patients should be warned to inform physician of use and report promptly any occurring gastrointestinal disturbances during administration because of risk of developing paralytic  ileus and impaired diagnosis of appendicitis. It should not be administered to children under 5and to patients in advanced age. It may mask the symptoms of toxicity of other medication. It may inhibit the cutaneous histamine response in skin tests using allergen extracts and produce falsenegative results therefore its use should be discontinued at least 27 h before testing.

Pregnancy and breast feeding:It should not be used during  the first trimester of pregnancy and during breast feeding it may inhidit lactation due to its anticholinergic activity. Excreted amounts in breast milk may cause inceased excitability irritability and sensitization in the breast fed infant.

Side effects:Signs and symptoms of hypersensitivity skin rash stomach upset and pain tiredness weaknss drowsiness dryness of mouth blurred vision which are transient or decrease after  dose reduction and may be prevented by concurrent use of caffeine.