Deteropine ( diphenoxylate Hydrochloride and atropine sulphate)

Presentation and Composition:

Each white uncoated tablets contains; Dippheoxylate Hydrochloride USP…… 2.5 mg

Atropine sulphate USP…… 25mcg;

Indication:

Therapy to provide symptomatic relief which may be adjunctive to appropriate rehydration therapy in diarrhea control of stool formation after colostomy or lieostormy; relie of symtomps in chronic mild ulcerative colitis.

Contradictions:

Detropine is contraindicated in patients with known hypersensitivity to diphenoxylate or atropine and in patients. Detropine is also contraindicated in patients with diarrhea associated with pseudomembranous or enterrotoxin- producing bacteria.

Warning:

Detropine is not an innocuous drug and dosage recommendation should be strictly to especially in children. Detropine is not recommendation for children under 4 years of age overdosage may result in severe respiratoty depression and coma, possibly leading to permanent brain damage or death . Therefore keep this medication out of reach of children.

Appropriate fluid and electrolyte therapy should be given to protect against dehydration. If severe dehydrolytes imbalance is present. Detropine should be with held until appropriate is corrective therapy has been initiated. Drug induced inhibition of peristaisis may result in fluid retention in the intestine, which may further aggravate dehydration and electrolyte imbalance.

Detropine should be used in extreme caution in patient with advanced hepatorenal disease and in all patients with abnormal liver function. Since hepatic coma may be precipitated. Bacterially induced diarrhea should be treated with appropriated antimicrobial therapy. In some patients with acute ulcerative colitis, agents which inhibit intestine motility or prolong intestine transit time have been reported to induce toxic megacolon.

Precaution:

A subtherapeutic dose of atropine has been added to detropine consideration should be given to the precaution relating to the use of atropine in children. Detropine should be used with caution since signs of atropinism may occur particularly in patients with Downs syndrome. Detropine may produce drowsiness or dizziness. The patients should be caution regarding activities requiring mental alertness. Such as driving or operating dangerous machinery. So keep out of reach of children.